Protective effect of pentoxifylline against renal ischemia-reperfusion injury in rabbits / 中国病理生理杂志

ABSTRACT

AIM:To study pentoxifylline(PTX) prevention against renal ischemia-reperfusion injury in rabbits. METHODS: 50 New Zealand rabbits were randomly divided into 5 groups sham operation groups, ischemia-reperfusion injury group(I/R), I/R+hypothermia group, I/R+PTX group and I/R +PTX+hypothermia group. Except the sham operation group, the rabbit left renal arteriae were blocked with bulldog clamps for 60 min. The left kidney was removed after 24 h. The activity of SOD, the content of MDA of kidney tissue homogenate, BUN and SCr in the blood were detected, meanwhile the pathological structure were observed. RESULTS: In I/R group, the renal tubule showed hydropic degeneration, hemorrhage and necrosis. A large number of inflammatory cells were infiltrated in the hemorrhage and necrotic tissue. The mitochondria of the proximal convoluted tubule epithelium were shown to be swollen highly, and the crisallia extremely confused, vague, disappeared. The injury was reduced in I/R+PTX group and I/R+hypothermia group. It was normal in the I/R+PTX+hypothermia group and sham group. The BUN, SCr, MDA in I/R group rised obviously and the activity of SOD was reduced significantly 24 h after reperfusion( P 0.05). CONCLUSION: PTX has a protective effect against renal ischemia-reperfusion injury.