Association Between Serum Leptin Levels and Tumor Necrosis Factor-alpha Levels in Congestive Heart Failure / 中国医师杂志

ABSTRACT

Objective To observe the changes of serum leptin(LP) levels and serum tumor necrosis tactor-alpha(TNF?) concentrations and to explore the relationships with fasting serum insulin levels and congestive heart failure(CHF).Methods Serum leptin and inslin concentrations were measured by radioimmunoassay and tumor necrosis factor-alpha by ELISA.Body mass index(BMI),mean arterial blood pressure(MBP),fasting serum insulin(FINS),LP and TNF-alpha levels were determined in 40 patients with CHF and in 20 healthy controls matched for gender,age,BMI and MBP.The correlations between leptin and other parameters were analyzed.Results ⑴The fasting serum LP and FINS concentrations of patients with NYHA grade Ⅲ and NYHA grade Ⅳ were significantly lower as compared with the controls(P0 05).⑵The TNF alpha was higher in heart failure patients that in healthy controls(P