Determination of the Content of Compound Tramadol Tablets by HPLC / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-520330
ABSTRACT
OBJECTIVE:
To establish a HPLC method to determine the content of compound tramadol tabletsMETHODS:
Stationary phaseKromasil C18 column,internal standardphenacetin,mobile phasemethanol-water-triethlamine(55∶45∶0 2),adjusting pH to 4 2 with acetic acid,flow rate∶0 7ml/min,detecting wavelength∶267nmRESULTS:
The linear range of tramadol (TR) was 50~500?g/ml(r=0 9 999,n=5) The linear range of nefopam(NFP) was 50~500?g/ml(r=0 9 999,n=5) The average recovery of TR was 99 69% The average content of TR was 100 71%,RSD=0 76%(n=5) The average recovery of NFP was 99 76% The average content of NFP was 99 64%,RSD=0 62%(n=5)CONCLUSION:
The method is accurate,rapid and simple
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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