Determination of the Concentration of Zaleplon in Human Plasma by HPLC / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-520475
ABSTRACT
OBJECTIVE:
To build up a method for determining the concentration of zaleplon in human plasma by HPLC.METHODS:
The Kromasil-C 8 column was used and mobile phase consisted of methanol-water(65∶35);the flow rate was1.0ml/min,fluorescence excitation wave-length was233nm;fluorescence emission wave-length was460nm.RESULTS:
The calibration curve revealed linearity in the concentration range of0.42~73.92ng/ml(r=0.9999)with a regressive equation of Y=1.870?147.The average recovery was99.47%.The with-day and between-day RSDs were4.9%and4.73%respec?tively.CONCLUSION:
The method is accurate,reliable and highly sensitive so it can be used in study of pharmacokinetics of zaleplon.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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