Fragile histidine triad gene deletion in breast cancer and its correlation with human papillomavirus infection / 中国普通外科杂志

ABSTRACT

Objective To investigate the deletion of fragile histidine triad (FHIT) gene in breast cancer and explore its relation with human papillomavirus(HPV) infection. Methods Thirty-eight breast cancer specimens and ten normal breast tissues were examined for abnormalities of FHIT gene by RT-PCR and fragment of HPV-DNA by PCR. Results The positive rates of FHIT gene deletion and HPV-DNA fragment were 63.1%(24/38) and 31.6%(12/38) respectively, while they were not detected in normal tissues (? 2=12.632,P