Advances in molecular mechanism in regulation of osteoclastogenesis / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-520513
ABSTRACT
Osteoprotegerin(OPG) ,receptoractivatorofNF -?Bligand (RANKL)andreceptoracti vatorofNF -??(RANK)areimportantmoleculesthatregulateosteoclastogenesis .OPGisdecoyreceptorof RANKL .ThebindingofOPGandRANKLblocksconnectingofRANKLandRANK ,inhibitsdevelopmentof osteoclast.ThebindingofRANKLandRANKinducesaserieskinasecascadereaction ,activatestranscription factors,introducestheproliferationanddifferentiationofosteoclastprecursors .Severalhormonesandos teotropicfactorsregulatetheformationandfunctionofosteoclastthroughtheabovemolecules .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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