Dose-Response Relationship between Catalase and Superoxide dismutase Activity in Testes of Acutely Intoxicated Rats by Cadmium / 예방의학회지
Korean Journal of Preventive Medicine
;
: 295-306, 1988.
Article
in Korean
| WPRIM
| ID: wpr-52066
ABSTRACT
Dose-response relationship among blood cadmium concentrations, catalase and superoxide dismutase activities were studied with acutely intoxicated rats by cadmium. The Sprague-Dawley male rats to which single dose of 1-32 mg/kg CdCl2 were administered into peritoneal cavity were sacrificed by decapitation at 3-36 hours after the administration. Cadmium concentrations in blood increased significantly with dose of CdCl2 administered and reached peak level at 3 hours later. Catalase activities in rats' tests were not correlated with exposure time elapsed after the administration in rats to which 1-2 mg/kg of CdCl2 were administered, but they showed linear relationship with time in groups to which 4-32 mg/kg of CdCl2 were administered. Cu, Zn-SOD activities in tests of acutely intoxicated rats by cadmium were not altered either by dosage or by time elapsed after the administration. Mn-SOD activities in the tests were also not influenced by dosage of 1-2 mg/kg CdCl2, but remarkably inactivated by dosage of 4-32 mg/kg CdCl2 with time elapsed after the administration. Neither catalase, Cu, Zn-SOD nor Mn-SOD activities of tests were correlated with blood cadmium concentrations in acutely intoxicated rats by cadmium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritoneal Cavity
/
Superoxide Dismutase
/
Testis
/
Cadmium
/
Catalase
/
Rats, Sprague-Dawley
/
Superoxides
/
Cadmium Chloride
/
Decapitation
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Preventive Medicine
Year:
1988
Type:
Article
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