Protective Effects of Verapamil on Ischemic Precondition for Resection of Liver / 中国医师杂志
Journal of Chinese Physician
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-520716
ABSTRACT
Objective To study the protective effect of verapamil against ischemia reperfusion injury when liver was resected.Methods The routine Pringle's maneuver hepatic vascular occlusion in 18~20min. Thirty-nine patients for resection of liver with cirrhosis were randomly divided into two groups, Verapamil group (n=20), the 20 patients with hepatectomy were given by 5mg verapamil through right gastroepiploic vein before blocking porta hepatis.Physiologic saline group (n=19), were injected by 20ml saline in the same way.The variation of postoperative liver function were measured.Liver intracellular [Ca 2+ ]i and adenosine triphosphate (ATP) after being reperfused for 1h were measured as well as the hepatic histopathologic alterations were also examined.Results The levels of intracellular [Ca 2+ ]i concentrations,alanine aminotransferase (ALT) and aspartate aminotransferase(AST)from the verapamil group increment less than those of the physiologic saline group(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2001
Type:
Article
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