Determination of the Concentrations of Salicylic Acid in Serum With RP-HPLC and Its Application / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-520759
ABSTRACT
OBJECTIVE:
To develop a RP-HPLC method for the determination of salicylic acid in serum and to apply this method to the pharmacokinetic and bioavailability study of salycylic acid in compound aspirin preparations.METHODS:
Waters2690HPLC instrument was used with Diamonsil C 18 column(5?m,250mm?4.6mm)as stationary phase and methanol-ace?tonitrile-0.2%phosphoric acid(18∶32∶50)as mobile phase at a flow rate of1.0ml/min,and the detective wavelength was237nm.RESULTS:
Calibration curve of salicylic acid was linear in the range of0.40~101.00?g/ml(r=0.9999).CONCLUS_ IONThe method is simple,sensitive,rapid and suitable for pharmacokinetic and bioavailability study of salicylic acid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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