Study on the Percutaneous Permeability Kinetics of Baicalin in Nude Mice / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-520869
ABSTRACT
OBJECTIVE:
To study the kinetics of percutaneous permeability of baicalin in nude mice.METHODS:
The transdermal constants of baicalin via nude mouse’s skin were determined,and the effects of stratum corneum on the kinetics studied.RESULTS:
The kinetic equation of baicalin via nude mouse’s skin was Q=76.07T 1/2 -32.11,while the kinetic equa?tion of baicalin via nude mouse’s skin without stratum corneum was Q=134.25T 1/2 +29.07,and there was baicalin exuded from skin after detachment of patch.CONCLUSION:
The kinetics of the patches is accord with the characteristics of frame?work type;the main barrier for baicalin permeance is stratum corneum and the skin without stratum corneum could store drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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