Protective effects of NF-kappa B inhibitor on ischemia/reperfusion injury in rat liver transplantation / 中国普通外科杂志
Chinese Journal of General Surgery
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-521159
ABSTRACT
Objective To study the effect of nuclear factor-?B(NF?B) on cytokins expression and neutrophil accumulation in murine liver transplantation. Methods Donor and recipient Wistar rats were pretreated by introperitoneal injection of proline dithiocarbamates(ProDTC, 15 mg/kg) 15 min before transplantation. Results Compared with NS control rats the level of NF?B p65 significantly decreased suppressing the transcription of TNF-?,MIP-2 and ICAM-1 and the release of serum TNF-? and MIP-2 as well as the activity of myeloperoxidase(MPO) in rats receiving ProDTC(all P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of General Surgery
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS