Molecular mechanism of immune cells activated by bacterial DNA / 中国病理生理杂志

ABSTRACT

Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited into endosome to recognize bacterial DNA and initiate the TLR/IL-1R signal transduction pathway. As a result , transcription factors NF-?B and AP-1 are activated, which, in turn, leads to proinflammatory cytokine expression and induces a strong acute Th1-like inflammatory response.