Protective Effects and Mechanisms of Anisodamine on Experimental Liver Injury / 中国医师杂志

ABSTRACT

Objective To investigate the protective effects and the mechanisms of anisodamine on experimental liver damage. Methods The experimental liver injury model was established by ANIT and CCl 4.Studies were made after ANIT or CCl 4 administration,and the control group compared with the experimental groups which were treated by anisodamine on the pathologic morphology, biochemical indices and the contents of Ca 2+ ,MDA and the ability of total antioxidation in the liver.Effects of anisodamine on sleeping time of the mice toxicated by given sodium phenobarbital were also determined.Results The elevation of ALT, ALP, BiL, CHE and the decrease of serum protein in ANIT or CCl 4 liver damage were significantly improved by treatment with anisodamine .It also remarkably diminished the hepato-cellular and chole-epthelial-cellular degeneration and necrosis induced by ANIT or CCl 4.The contents of Ca 2+ ,MDA and the ability of total antioxidation in the liver were all decreased by treatment with anisodamine. The sleeping time induced by sodium phenobarbital in the toxicated mice was reduced by anisodamine. Conclusion Anisodamine have significant protective effects on liver injury of intrahepatic cholestasis and chemical hepatitis and the mechanism may be associated with blocking M-receptor and enhancing antioxidation and antitoxic activity in liver.