Inhibition of the formation of experimental abdominal aortic aneurysms by PI-88 / 中国普通外科杂志

ABSTRACT

Objective To evaluate heparanase inhibitor PI-88 in the inhibition of abdominal aortic aneurysm(AAA) formation. Methods A guinea pig-to-SD rat transplantation model of AAA was established for the observation of therapeutic effects of PI-88 given by continuously administration within 4 weeks after abdominal aortic transplantation. Abdominal aortic diameter, the degree of inflammatory infiltration, microvessel density and the expression of heparanase were determined by immunohistochemistry and Northern blot analysis. Results In contrast to the positive controls, the diameter and inflammatory cell infiltration of graft decreased remarkably after administrating PI-88, and the expression of heparanase and microvessel density decreased accordingly, although still upregulated when compared with negative control. Conclusions PI-88 could prevent formation of AAA by inhibiting heparanase activation.