Effects of Naomaikang on the Platelet Aggregation Rate and Pathomorphological Changes of Experimental Atherosclerosis Rabbits / 中国药房

ABSTRACT

OBJECTIVE:To investigate the inhibiting effect of Naomaikang(NMK) on atherosclerosis(AS) METHODS:Healthy male california rabbits were randomized into 5 groups(n=10)normal group,model group,Fenofibrate group,NMK groupⅠ(2ml) and NMK group Ⅱ(1ml) The rabbits in each group,except the normal one,were fed with hypercholestrol diet and the medicines were given to the other three groups at the same time The blood of each group was sampled for determining the platelet aggregation rate(PAR) before and after experiment The aorta of rabbit in each group was dissected out and stained with oil red 0,then the areas and incidences of plaque on aorta wall were calculated,the aortic arch was taken to observe under the light and electron microscopes RESULTS:The PAR in model group was significantly increased compared with those in other groups(P