Clinical Analysis of243Patients with Vitiligo and the Association with HLA-DQB1 / 中华皮肤科杂志

ABSTRACT

Objective To analyze the clinical features and two HLA-DQB1alleles in their associa-tions with vitiligo.Methods Clinical data of243patients with vitiligo were collected and the HLA-DQB1al-leles were determined by a PCR-SSP assay in both patients and control groups.Results The mean age of the first onset was23.1years for the males,and23.7years for the females.The localized type was the major form in the initial stage.The segmental type mainly occurred in childhood.Age of the first onset was younger in pa-tients with familial history than those in patients without familial history.HLA-DQB1*0201allele was associ-ated with non-segmental type only.Conclusions①The pathogenesis might be different between non-segmen-tal and segmental vitiligo.②Polygenic inheritance may explain vitiligo with familial history.There might be a difference of genetic background between vitiligo with or without familial history.③HLA-DQB1*0201allele may be the susceptible gene or have close linkage with susceptible gene in vitiligo vulgaris.