Effects of Electric Stimulating Insular Cortex of Rat on ECG and Heart Rate Variability / 中国医师杂志

ABSTRACT

Objective To assess the effects of electric stimulating insular cortex on ECG and heart rate variability(HRV) in rats. Methods ⑴The total of 36 healthy male Wistar rats were randomly divided into control group and electric stimulating group, and ECG was observed after electric stimulating insular cortex 1 hour with 500uA,50HZ current intensity. ⑵The total of 42 healthy male Wistar rats were randomly divided into sham group,control group and electric stimulating group, then the control group and electric stimulating group were further divided into 70uA,500uA,1500uA,50HZ stimulating groups, each group containing 6 rats. Blood pressure, heart rate and HRV were observed after electric stimulation 1 hour. Results ⑴The ECG showed change,and heart rate and blood pressure of rats in the electric stimulating group significantly increased at 500uA after electric stimulation 1 hour compared with sham and control groups. ⑵The measured components of HRV of 500uA and 1500uA stimulating groups, such as percentages of NN intervals differences