Study on the Stability of Amoxicillin Sodium and Clavulanate Potassium for Injection in Sodium Chloride Injection Solution / 中国药房

ABSTRACT

OBJECTIVE:To study the stability of amoxicillin sodium and clavulanate potassium for injection in sodium chloride injection solution so as to offer a scientific basis for rational use of drug in clinical practice.METHODS:The external appearance and pH values of the mixed solution were observed,and the contents of Amoxicillin sodium and Clavulanate potas?sium were determined by HPLC method at5℃,25℃and37℃within3hours.RESULTS:The stability was related to the temperature and sunlight.CONCLUSION:The mixed solution is instable and should not be put in storage for long time.