Effect of Glucocorticoid on Disbalance of Th_1/Th_2 Cytokines in Asthmatic Patients / 中国医师杂志

ABSTRACT

Objective To explore the effect of glucocorticoid on disbalance of the Th 1/Th 2 cytokines to investigate the mechanism of treatment of breathing in glucocorticoid in asthmatic patients. Methods The peripheral blood was drawn and the plasma IL-4,IL-12 and IgE of control group and patients were detected by ELISA method before and after glucocorticoid treatment. The results were analysed statistically. Results ⑴In asthmatic group, plasma IL-4 and IgE levels, and PEF variant rate after treatment were lower than those before treatment (P0.05); and ⑷ Correlation analysis showed that IL-4 level positively correlated with the IgE level and PEF variant rate(r=0.64,r=0.52;P