The Expression of Interleukin-17,Interferon-?,and Macrophage Inflammatory Protein-3?mRNA in Patients with Psoriasis Vulgaris / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12)1995.
Article
in Chinese
| WPRIM
| ID: wpr-522204
ABSTRACT
Objective To investigate the expression levels of of interleukin-17(IL-17),interferon-gamma(IFN-?),and macrophage inflammatory protein-3alpha(MIP-3?)mRNA in skin lesions of pa-tients with psoriasis vulgaris.Methods The skin biopsies were collected from skin lesions in31cases of psoriasis vulgaris and16normal controls.The expressions of IL-17,IFN-?,and MIP-3?mRNA were semi-quantitatively analyzed with reverse transcriptase-polymerase chain reaction(RT-PCR)in psoriatic lesions and normal skin tissues.Results Expressions of IL-17,IFN-?,and MIP-3?were presented in all speci-mens of both psoriatic lesions and normal controls.The expression levels were1.142?0.059for IL-17mRNA,1.114?0.056for IFN-?mRNA,1.140?0.052for MIP-3?mRNA,in skin lesions,respectively,which were greatly higher than those in normal controls(0.879?0.034,0.905?0.026and0.868?0.031,respectively)(all P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
1995
Type:
Article
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