Therapeutic effects of losartan and astragalus membranaceus on diabetic nephropathy / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-522434
ABSTRACT
AIM:
To observe the protective effects of losartan and astragalus membranace on the kidney of diabetic rats, and to study their possible mechanisms.METHODS:
The diabetic rats were induced by a single intraperitoneal injection of streptozotocin. At the end of 12th week,changes in urinary albumin excretion, urinary ? 2-MG excretion, Ccr,NO,ET-1 levels in blood, urinary and renal tissue were observed. Serum and urinary TGF-? 1 concentration,average volume of glomeruler,average thickness of glomerular basement membrane were also measured.RESULTS:
In the treated diabetic rats, urinary albumin excretion, urinary ? 2-MG excretion, Ccr, urinary and renal tissue NO, urinary TGF-? 1, average volume of glomeruler, average thickness of glomerular basement membrane decreased obviously as compared with diabetic untreated rats. These effects were enhanced when losartan was combined with astragalus membranace.CONCLUSION:
Losartan or astragalus membranace reversed the injury of renal structure and function in STZ-induced diabetic rats. The protective effects were enhanced when losartan was combined with astragalus membranace. The decrease in NO,ET,TGF-? 1 concentration in renal tissue may be one of mechanisms for this action.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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