Involvement of bFGF in the lung response to silica in a mouse model / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-522436
ABSTRACT
AIM:
To investigate the relationship between basic fibroblast growth factor (bFGF) and the development of silicosis in mice.METHODS:
MTT test was utilized to examine the effects of bFGF-neutralizing antibody and the bronchoalveolar lavage fluid (BALF) of the mice exposed to silica on lung fibroblast cell growth.RESULTS:
BALF from mice treated intrabronchially with silica promoted the growth of lung fibroblasts and anti-bFGF antibody inhibited the effect of BALF dramatically.CONCLUSION:
These results indicates that bFGF secretion increases in lung in a mice silicosis model and participates in the development of silicosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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