Effects of recombinant viral chemokine vMIP-II on cellular immunity stimulated by LPS / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1989.
Article
in Chinese
| WPRIM
| ID: wpr-522613
ABSTRACT
AIM:
To investigate the produce of intracellular cytokine following short-term in vitro stimulation with vMIP and LPS, and discuss the effect of vMIP to cellular immunity.METHODS:
The methods of Cross-linking of radioactivity, ELISA and four-colors flow cytometer were used to test the level of the secretion of chemokine IL-12 and intracellular cytokine IFN-? and IL-4.RESULTS:
After treated the PBMCs with vMIP-II, the levels of secretion of IL-12, IFN-? and IL-4 were reduced in the present of LPS by competitively combining chemokine receptor; vMIP promoted CD4+T cell to secrete IL-12, IFN-? and IL-4.CONCLUSION:
vMIP-II can protect systemic response of immunity and reduce extremely inflammation by down-regulating proinflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1989
Type:
Article
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