Pharmacokinetics of Zaleplon Tablets in Chinese Healthy Volunteers / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-522643
ABSTRACT
OBJECTIVE:
To study the pharmacokinetics of domestic zaleplon tablets in Chinese healthy volun?teers.METHODS:
20male healthy subjects received a single oral dose of15mg zaleplon tablets.The plasma concentrations of zaleplon were determined by an improved HPLC method.RESULTS&CONCLUSION:
The main pharmacokinetic parameters of zaleplon were as followC max was55.90?16.20ng/ml,T max was1.05?0.32h,Ke was0.74?0.18h -1 ,T 1/2Ke was1.00?0.29h,AUC 0~8 was123.70?25.64ng?h/ml,AUC 0~∞ was125.20?25.80ng?h/ml.The results are compara?ble to those reported in foreign literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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