Study on Decreasing Effects of Polydatin on Blood Viscosity in the Rat Model of Acute Blood Stasis / 中国药房

ABSTRACT

OBJECTIVE:To observe the decreasing effects of Polydatin on blood viscosity and microcirculation in the rat model of acute blood stasis.METHODS:The rat model of acute blood stasis was established with high dose of adrenaline sub?cutaneous injection in combination with ice-water socking.The parameters such as whole blood viscosity?bat low and high shear rates,hemotocrit,platelet adhesiveness testPAdT,fibrinogenFIB,plasma viscosity?petc.were used.RESULTS:The results showed that Polydatin reduced FIB,PAdT in rat model remarkably.It obviously caused a reduction of?p,which induced decrease of?b.The effect was more significant than any other factors in reducing blood viscosity and improving mi?crocirculation.CONCLUSION:Polydatin is helpful to reduce blood viscosity and improve microcirculation.The data provided would be useful for rational use of drug.