Expression and Significance of TGF-?_1 in the Placenta of Patients with Pregnancy-induced Hypertention / 中国医师杂志
Journal of Chinese Physician
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-522922
ABSTRACT
Objective To study expression and clinical significance of TGF-? 1 in the placenta of the patients with pregnancy-induced hypertension(PIH). Methods The SABC immunohistochemical method was performed to determine the location and intensity of TGF-? 1 expression in placental tissues of 64 patients with PIH and 20 normal pregnant women. Results TGF-? 1 expression was principally localized in the trophoblast and decidual cells. The expression level of TGF-? 1 in the trophoblasts and decidual cells significantly increased in the patients with PIH compared with the normal pregnant women, and elevated with the severity of PIH increased. A negative relation was found between the expression level of TGF-? 1 and the weight of placenta and neonate in the patients with PIH. Conclusion The elevated expression of TGF-? 1 in placenta leads to the deficiency of trophoblast cell invasion, which may be one of the pathogenic causes of PIH.
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2001
Type:
Article
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