Expression of insulin-like growth factor-Ⅱ and its mRNA in PIH Placenta / 中华围产医学杂志
Chinese Journal of Perinatal Medicine
; (12)2000.
Article
in Zh
| WPRIM
| ID: wpr-523001
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WPRO
ABSTRACT
Objective To investigate the expression of insulin-like growth factor-Ⅱ( IGF-II ) and its mRNA in human placenta and to evaluate its role in the pathogenesis pregnancy induced hypertension (PIH). Methods The cellular distribution of IGF-Ⅱin normal and PIH placenta was determined by immunohistochemistry. Trophoblasts were digested,separated,and purified from placenta. IGF-ⅡmRNA expression in trophoblasts was detected by RT-PCR. The mean density was determined by image analysis technique. Results (1) IGF-Ⅱwas mostly found in syncytiotrophoblast,cytotrophoblast and amnio-chorion. The strongest immunoreactivity was observed in the syncytiotrophoblast and cytotrophoblast. (2)The mean density of PIH placenta (0.324?0.042) was significantly lower than that of normotensives (0.360?0.072,P
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Perinatal Medicine
Year:
2000
Type:
Article