Effect of 1 mg of prophylactic haloperidol for postoperative nausea and vomiting after gynecological laparoscopic surgery using IV patient controlled analgesia
Anesthesia and Pain Medicine
;
: 30-34, 2010.
Article
in Korean
| WPRIM
| ID: wpr-52307
ABSTRACT
BACKGROUND:
Haloperidol, a major tranquilizer similar to droperidol, has been found to have a potent antiemetic effect on postoperative nausea and vomiting (PONV), but the supporting evidence was incomplete, especially in Korea.Therefore we evaluated the prophylactic effect of haloperidol on opioid-based IV patient-controlled analgesia (PCA) related PONV in susceptible patients after gynecological laparoscopic surgery.METHODS:
Ninety-six adult women scheduled gynecological laparoscopic surgery were enrolled in a randomized, double-blinded and placebo study.Patients received haloperidol 1 mg (Group H) or saline (Group C) 30 min before the end of surgery.Fentanyl-based IV PCA was administered after surgery.The incidences and severity of nausea, vomiting, rescue antiemetic administration, pain, and adverse effects (cardiac arrhythmias and extrapyramidal effects) were assessed for 24 h after surgery.The sedation score was recorded in the post-anesthesia care unit for 2 h.RESULTS:
The incidences and severity of nausea and the number of antiemetic administration were significantly lower in Group H than Group C (P < 0.05). But the sedation and pain score were similar. There was no QTc prolongation or extrapyramidal symptom in both groups.CONCLUSIONS:
Prophylactic haloperidol 1 mg is effective in preventing PONV related to fentanyl-based IV PCA, with less adverse effects, in patients undergoing gynecological laparoscopic surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Vomiting
/
Passive Cutaneous Anaphylaxis
/
Incidence
/
Analgesia, Patient-Controlled
/
Laparoscopy
/
Postoperative Nausea and Vomiting
/
Droperidol
/
Haloperidol
/
Antiemetics
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
Anesthesia and Pain Medicine
Year:
2010
Type:
Article
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