Expression and clinical significance of DNA topoisomerase and glutathione S-transferases in acute leukemia / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1999.
Article
in Chinese
| WPRIM
| ID: wpr-523303
ABSTRACT
AIM:
To investigate the relationship between the expressions of DNA topoisomerase (Topo), glutathione S-transferases (GSTs) and chemotherapy response, prognosis in acute leukemia (AL).METHODS:
Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of TopoⅠ, Ⅱ?, Ⅱ? and GST?, ? from patients with AL.RESULTS:
The results showed that the relative mRNA expression level of TopoⅡ?, TopoⅡ? and GST ? in AL group were significantly higher than that in normal subjects. GST?, however, was exactly reverse ( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1999
Type:
Article
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