Preparation of Diclofenac Sodium Controlled Release Pellets and Study on the Release Behaviour / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-523351
ABSTRACT
OBJECTIVE:
To prepare diclofenac sodium controlled release pellets and investigate the mechanism of re?lease.METHODS:
Single-factor method was used to investigate the influence of the composition of solvent system in coating solution,the concentration of coating material,porogenic agent and plastifier on the release rate of drug.RESULTS:
When the concentration of coating material and the proportion of water increased,the release rate of pellets was increased;the release rate was further increased with PVP K30 added.CONCLUSION:
The pellets belongs to the matrix-coating pellets,and the release mechanism varies with the change of coating thickness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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