Influence of acute hypervolemic hemodilution combined with controlled hypotension on glomerular filtration rate and blood gases and electrolytes in patients undergoing spinal surgery / 中华麻醉学杂志

ABSTRACT

20% . In both groups CH was induced with infusion of 0.01% sodium nitroprusside (NTP) to maintain MAP at 55-65 mm Hg. MAP, HR, CVP cardiac output were continuously monitored. Arterial blood samples were taken before (T0 ) and after AHH (T1 ) , 30 min after CH was induced (T2 ) and 30 min after tennination of CH (T3 ) for blood gas analysis and determination of plasma levels of electrolytes and ?2-microglobulin.Results The two groups were comparable with respect to the demographic data including age, body weight and height. In group Ⅰ pH was significantly decreased after AHH and CH (T1-3) compared to the baseline (T0 ) and was significantly lower than that in group Ⅱ . There was no significant difference in plasma K+ , Na+ , Ca2+ , Cl- and BE between the two groups. Plasma?2- MG decreased significantly after AHH (at T1 ) compared to the baseline value before AHH (T0) in group Ⅰ and was significantly lower than that ingroup Ⅱ at T1-3 . Conclusion Glomerular filtration rate decreases during controlled hypotension as shown by increased plasma?2-MG. AHH combined with CH can improve glomerular filtration rate while exerts no significant effects on blood gases and electrolytes.