Preliminary study on pathogenesis of achalasia / 中华消化内镜杂志

ABSTRACT

Objective To elucidate the pathogenesis of achalasia, Benzyldimethyltetradecylammo-nium chloride ( BAC) was used to create amyenteric cat achalasia models. Methods Twenty-four cats were randomized into two groups and injected respectively with BAC in models or saline in controls into the distal esophagus under endoscopy. After 8 weeks, manometry, biopsy with HE stain, acetylcholinesterase activity and immunohistochemistry were studied. Results Manometrically, the pressures of LES in cat models showed higher than those of the controls (P