Protective effect of rapid ischemic preconditioning against spinal cord ischemic injury in rabbits / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-523700
ABSTRACT
AIM:
To evaluate the protective effect of rapid phase of ischemic preconditioning against spinal cord ischemic injury in rabbits.METHODS:
Thirty six male New Zealands white rabbits were randomly assigned to 3 groups (12 in each group) ischemia and reperfusion injury group (IR group), ischemic preconditioning + IR group (IPC+IR group) and sham operation group (sham). In IR group, spinal cord ischemia was induced by an infrarenal aorta clamping for 20 min; The rabbits in IPC+IR group underwent a 6 min ischemic preconditioning followed by 30 min of reperfusion before the 20 min clamping; The rabbits in sham group underwent the same procedures as the IR group except for infrarental aortic unclamping. Neurologic status was scored at 8, 12, 24 and 48 h after reperfusion. All animals were sacrificed at 48 h after reperfusion and the spinal cords (L_(5-7)) were removed for histopathologic study and determination of the activity of Na~+, K~+-ATPase.RESULTS:
The neurologic function scores in sham group and IPC+IR group at each observation interval were higher than those in IR group (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2000
Type:
Article
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