Effect of indomathacin on levels of PGE_2、PGI_2 and TXA_2 in experimentally inflamed pulp in rats / 中国病理生理杂志

ABSTRACT

AIM: To study the effect of local application of indomethacin on acute pulpitis. METHODS: Traumatic pulpitis model in rats was established by means of pulp exposure, radioimmunoassay (RIA) was used to measure the kinetic changes of the levels of PGE_2、6-keto-PGF_~1? and TXB_2 of pulpal tissues. RESULTS: Local application of indomethacin could more effectively inhibit the cyclo-oxygenase pathway than zinc oxide engenol in the early stage of pulpitis and reduce the production of prostaglandins. CONCLUSION: Local application of indomethacin may have a therapeutic effect on acute pulpitis. [