Effects of Melatonin on the Influx of Ca~(2+) Induced by L-glutamate in Cultured Rat Neurons / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-524125
ABSTRACT
OBJECTIVE:
To study the inhibitory effect of melatonin(MT)on the increased influx of Ca 2+ induced by L-glutamate in cultured rat neurons.METHODS:
Fura-2/AM,a Ca 2+ sensitive fluorescent indicator was used to load the brain cells isolated from new-born rats,and the intracellular dissociative Ca 2+ concentration(〔Ca 2+ 〕i)was measured with fluores?cence-spectrophotometer.RESULTS:
The L-glutamate of concentration500?mol/L could markedly promote the influx of Ca 2+ and intracellular free Ca 2+ concentration(P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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