A Study on Relationship Between Antinucleosome Antibody and Systemic Lupus Erythematosus / 中国医师杂志

ABSTRACT

Objective To explore relationship between antinucleosome antibody and desease activity of systemic lupus erythematosus(SLE). Methods Serum antinucleosome antibodies were measured by ELISA in the 88 patients with SLE. The relationship among antinucleosome antibodies, disease activity ( evaluated using SLEDAI), anti-dsDNA antibody and complements was analyzed. Results Antinucleosome antibody was positive in 70 patients with SLE (79.5%). There were correlations between the antinucleosome antibody and SLE disease activity, anti-dsDNA antibody, complement C3, erythrocyte sedimentation rate. Conclusion Antinucleosome antibody is a relatively sensitive marker in diagnosing SLE and evaluating SLE disease activity.