Chemokine receptor CXCR4 and its ligand SDF-1 in the pathogenesis of ankylosing spondylitis / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-524280
ABSTRACT
AIM:
To determine the role of chemokine and its receptors in the pathogenesis of ankylosing spondylitis (AS).METHODS:
Gene expression profiles of peripheral blood mononuclea r cells (PBMC) in 13 AS patients and 7 healthy volunteers were determined by cDN A microarray with 588 targeting gene filter. Differentiated expressed CXCR4 and its only ligand SDF-1 were confirmed by semi-quantitative RT-PCR, ELISA, immunoh istochemistry and FACS analysis using PBMC, synovial fluid mononuclear cells (SF MC) and synoviocytes.RESULTS:
The gene expression profile of AS patients was signific antly different from those of healthy volunteers. Higher expression of CXCR4 in monocytes and CD8+ T lymphocytes from PBMC in AS patients were found with st atis tical significance (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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