Study of the Effect of Dimethylsulfoxid(DMSO)on Function of Platelet in Vitro / 中国药房

ABSTRACT

OBJECTIVE:To explore the effect of dimethylsulfoxid(DMSO)on the activity and function of platelet in vit?ro.METHODS:Fresh random-donor platelet unit(n=60)were divided into3equal groups.A DMSO-free group was chosen as a control group.The other two groups included a washed platelet group and a DMSO group to which DMSO was added with a final concentration of3%.All the groups were stored on a horizontal shaker at room temperature.Changes of adherence rate,aggregating function and recovery rate from hypotonic shack of platelet were observed.RESULTS:In the DMSO group,platelet adherence rate,aggregating function,and recovery rate from hypotonic shack decreased during storage comparing with control and washed platelet groups.CONCLUSION:DMSO has a protective effect on platelet and its action is reversible.