Determination of Cilostazol Concentration in Human Plasma by HPLC / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-524418
ABSTRACT
OBJECTIVE:
To propose a HPLC method for quantitative assessment of cilostazol in human plasma.METHODS:
Chromatogram column was C18(150mm?4.6mm, 5?m), mobile phases were acetonitrile-water(40∶60,V/V), the flow rate was 1.4ml/min,determined wavelength was 254nm.RESULTS:
Cilostazol concentration was in the linear range of 25~2000ng/ml(r=0.9 999)with the lowest determinable concentration of 12.5ng/ml,recoveries of cilostazol from plasma were 99.99%~101.44%,the relative standard variation of intra-day and inter-day were 0.20%~2.90% and 0.19%~2.13%(n=5) respectively.CONCLUSIONS:
This method is s simple, convenient, accurate, and applicable for study of pharmacokinetics of cilostazol in clinic.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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