Norcantharidin induces HeLa cells apoptosis through caspases pathway / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-524472
ABSTRACT
AIM:
To examine the apoptotic pathway of norcantharidin (NCTD)-induced HeLa cells death.METHODS:
MTT, photomicroscopical observation, DNA agarose gel electrophoresis, LDH release and Western blot analysis were used.RESULTS:
NCTD induced HeLa cells apoptosis and the apoptosis was partially reversed by the inhibitors of caspase-family (-3, -8, -10). The activities of caspase-3, -8 and -9 were significantly increased after treated with NCTD. The expression of the inhibitor of caspase-3 activated DNase (ICAD) was decreased in a time dependent manner.CONCLUSION:
NCTD induces HeLa cells apoptosis through activating caspase pathways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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