Contents Determination of2Compositions in Liquor Nitrofurazoni Solution by RP-HPLC / 中国药房

ABSTRACT

OBJECTIVE:To establish a RP-HPLC method for simultaneous determination of furacillin and sodium ben-zoate in furacillin solution.METHODS:Shim-pack C 8 was used as the chromatographic column;the mobile phase was methanol-water(35∶65),the detecting wavelength was240nm.RESULTS:The linear ranges of furacillin and sodium ben-zoate were1.0～40.0?g/ml(r=0.9998)and5.0～200.0?g/ml(r=0.9996)respectively,the average recovery was100.1%(RSD=1.52%)and99.7%(RSD=1.57%)respectively.CONCLUSION:The method is simple,rapid and accurate and it can be used for the quality control of furacillin solution.