Antagonistic effect of bilirulin on acute lung injury induced by LPS in rats / 中国病理生理杂志

ABSTRACT

AIM: To investigate the effect of bilirub in on acute lung injury (ALI) and the mechanism. METHODS: 30 male Wistar rats were divided into normal group, ALI group and bilirubin treatment group. Lung specimens were examined by histopatho logical te chnique. Lung index (LI) and lung permeability index (LPI) were measured. Moreov er, white blood cell (WBC) count, neutrophil percentage (PMN%) and the content o f protein (Pr) in the bronchoalveolar lavage fluid (BALF), as well as the conten ts of sup eroxide dismutase (SOD), malonaldehyde (MDA) and glutathione peroxidase (GSH-Px) in the lung homogenate were determined. RESULTS: (1) In ALI group: LI, WBC count, PMN%, Pr and LPI incre ased significantly compared with normal group (P 0.05) was observed. (2) In ALI group, the content of MDA was significantly high er (P0.05). CONCLUSION: Bilirubin relieves ALI induced by LPS in rats via an tioxidation.