Peripheral Blood Dendritic Cell Subsets in Patients with Condyloma Acuminata / 中华皮肤科杂志

ABSTRACT

Objective To determine the peripheral blood dendritic cell (DC) subsets in patients with condyloma acuminata (CA) and its significance. Methods The CD11c+ peripheral blood DC (DC1) and CD123+ DC(DC2) subsets were analyzed by flow cytometry with three-color immunofluorescent staining in 25 patients with CA and 26 healthy controls. Results The proportion of CD123+ peripheral blood DCs was significantly increased in patients with CA[(0.63 ? 0.34)%]in comparison with that in healthy controls [(0.41 ? 0.17)%](P 0.05). Conclusions The predominance of CD123+ DCs in peripheral blood of CA may favor Th2-dominated immunity, which may be related to recurrence and course of the disease.