Determination of Blood Concentration of Pioglitazone Hydrochloride by HPLC / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-524752
ABSTRACT
OBJECTIVE:
To establish the method of determining the blood concentration of pioglitazone hydrochloride.METHODS:
Chromatographic column was based on Hypersil C l8 (150mm?4.6mm,5?m),the mobile phase consisted of ace-tonitrile-buffer phosphate(40∶60,V/V)with a flow rate at l.0ml/min,the detecting wavelength was229nm.The blood sample was extracted with dichlormethane.RESULTS:
The linear concentration range was25~4000ng/ml(r=0.9998,n=8).The lowest detecting concentration was25ng/ml.The extracting recovery rate of high,medium and low concentrations were(73.33?1.22)%,(76.92?6.57)%and(84.50?3.40)%respectively,the method recovery which were(103.26?3.31)%,(97.31?9.07)%and(99.61?6.48)%respectively.The intra-day RSD
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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