Experimental Study of Low Molecular Weight Heparin Therapy for Kidney Injury in Severe Acute Pancreatitis / 中国医师杂志

ABSTRACT

Objective To investigate the effect of low molecular weight heparin (LMWH) on kidney injury in severe acute pancreatitis (SAP). Methods SD rats were randomly divided into 3 groups Sham operation (S) group,SAP group, and LMWH treatment (LT) group. In LT group LMWH was administrated 4 hours after SAP model establishment. The levels of serum amylase, creatinine (Cr) and tumor necrosis factor alpha (TNF-?), renal morphological change, and the expression of p65 mRNA and protein in renal specimens were determined 24 hours after model establishment or LMWH treatment. Results The levels of serum amylase,Cr,TNF-? in SAP group were significantly higher than those in S group and LT group (all P0.05). The expression of p65 protein and mRNA of renal tissues in SAP group was significantly higher than that in S group and LT group (all P