Effects of anthocyanin on cholesterol efflux from mouse peritoneal macrophage foam cells / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1989.
Article
in Chinese
| WPRIM
| ID: wpr-524924
ABSTRACT
AIM:
To explore the effect of anthocyanin on cholesterol efflux and elucidate its possible molecular mechanism.METHODS:
Mouse Peritoneal macrophages were loaded with 50 mg/L AcLDL to induce macrophage-derived foam cells. Cholesterol efflux from macrophage-derived foam cells induced by anthocyanin was determined by enzymatic methods. PPAR-? mRNA and protein expression in macrophage-derived foam cells was assayed by quantitative PCR and western blotting.RESULTS:
Anthocyanins had the capacity of promoting cholesterol efflux from mouse peritoneal macrophage-derived foam cells and increased PPAR-? mRNA and protein expression.CONCLUSION:
Anthocyain-induced cholesterol efflux may be related to its enhancing PPAR-? mRNA and protein expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1989
Type:
Article
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