HPLC Determination of Ketoconazole and Desamethasone Acetate in Ketoconazole Spraying Film Simultaneously / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-524960
ABSTRACT
OBJECTIVE:
To establish an approach to determination of ketoconazole and desamethasone acetate in novel ketoconazole spraying film.METHODS:
Chromatography was performed using a Waters Symmetry C 18 .The mobile phase consisted of methyl-monopotassium phosphate(4∶1).Detection wave was at239nm.The flowing rate was0.6ml/min.RESUL_ TSExcellent linear correlations were showed when the concentrations of ketoconazole and desamethasone acetate were in the ranges of0.2~2mg/ml and0.02~0.2mg/ml respectively.The mean recoveries of ketoconazole and desamethasone acetate were98.41%(RSD=2.29%,n=6)and97.84%(RSD=2.60%,n=6)respectively.CONCLUSION:
The established approach is precise,reliable and therefore applicable to the quality control of novel ketoconazole spraying film.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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