Study on Human Body Bioavailability of Troxipide Capsules and Tablets / 中国药房

ABSTRACT

OBJECTIVE:To study human body bioavailability of trosipide capsules and tablets.METHODS:18healthy men volunteers were administered randomly with cross single dose of capsules or tablets of trosipide.The blood concentrations of which were determined by HPLC and the pharmacokinetic parameters and the relative bioequivalency were calculated with3p97program.RESULTS:The human body concentration-time curves of capsules and tablets of trosipide were in line with two compartment model.The C max of capsules and tablets of trosipide were(1.01?0.26)?(0.99?0.35)?g/ml respectively;the T max were(3.39?1.04)?(3.33?1.19)h respectively;the AUC 0～48 were(10.16?2.40)?(10.46?2.85)(?g?h)/ml respective_ ly and the t 1/2ke were(5.60?0.22)?(6.50?2.35)h respectively.The relative bioavailability of troxipide capsules was(96.85?24.1)%.CONCLUSION:Troxipide capsules and tablets were bioequivalent.