Study on Pharmacokinetics of Escitalopram Oxalate Tablets in Human Body / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-525117
ABSTRACT
OBJECTIVE:
To study the pharmacokinetics of escitalopram oxalate tablets in human body.METHODS:
Es-citalopram oxalate tablets were administered orally at a single dose of30mg to10healthy subjects respectively,the plasma concentration of escitalopram oxalate was determined by HPLC method,the pharmacokinetic parameter was fitted with3p97software.RESULTS:
The concentration-time curve of escitalopram oxalate tablets was in line with the two-compartment model,the main pharmacokinetics parameters of escitalopram oxalate were as follows,the C max was(42.73?10.19)?g?L,t max was(2.90?0.32)h,t 1/2 was(35.34?7.78)h,AUC 0~132 was(1241.5?194.3)(?g?h)/L and the AUC 0~∞ was(1327.5?210.5)(?g?h)/L.CONCLUSION:
The study on pharmacokinetics can be used as a reference in the clinical medication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS