Study on Dissolution of Cefadroxil Tablets and Cefadroxil Capsules from Different Manufactures / 中国药房

ABSTRACT

OBJECTIVE:To compare the dissolution rates of cefadroxil preparations from A,B and C3manufacturers and to provide references for rational clinical drug use.METHODS:The contents were determined by UV-spectrophotometry with the detection wavelength at263nm;The dissolution was determined by oar method with water as the solvent and with rotation speed at50r/min,the stripping curves were drawn,the parameters of T d ,m and?were figured out,and on which ANOVA was conducted;Besides,the dissolution tests were conducted on cefadroxil capsules that from manufacturer C by oar method and baskets-rotating methods simultaneously and the results of which were subjected to t-tests.RESULTS:The values of T d and?of cefadroxil capsules and cefadroxil tablets had significant differences(P0.05),but sig?nificances were found in m value between2batches of cefadroxil tables;The dissolution values of2batches of capsules from manufacturer C were signficances determined by oar method and rotation basket method respectively for less than10min and20min(P